With computer genius Luther Stickell at his side and a beautiful thief on his mind, agent Ethan Hunt races across Australia and Spain to stop a former IMF agent from unleashing a genetically engineered biological weapon called Chimera. This mission, should Hunt choose to accept it, plunges him into the center of an international crisis of terrifying magnitude.

Retired from active duty to train new IMF agents, Ethan Hunt is called back into action to confront sadistic arms dealer, Owen Davian. Hunt must try to protect his girlfriend while working with his new team to complete the mission.